PUBLICATIONS

2025

Sarkar, S., Chang, CI., Jean, J, Wu MJ. TCA cycle-derived oncometabolites in cancer and the immune microenvironment. J Biomed Sci 32, 87 (2025). doi.org: 10.1186/s12929-025-01186-y. PMID: 40931345.

Zhang Z, Luo Z, Liu Y, Sahoo SS, Dembele V, Wu MJ, Bardeesy N, Huang F, Kazemian M, Cottrell KA, Tao WA. Proteomic Tracking Extracellular Vesicle RNA Interactors in Recipient Immune Cells through Orthogonal Labelings. J Am Chem Soc. 2025 Aug 13;147(32):28577-28582. doi: 10.1021/jacs.5c07631. Epub 2025 Aug 1. PubMed PMID: 40746261.

Vijay V, Karisani N, Shi L, Hung YH, Vu P, Kattel P, Kenney L, Merritt J, Adil R, Wu Q, Zhen Y, Morris R, Kreuzer J, Kathiresan M, Herrera Lopez XI, Ellis H, Gritti I, Lecorgne L, Farag I, Popa A, Shen W, Kato H, Xu Q, Balasooriya ER, Wu MJ, Wan J, Kondo H, Chaturantabut S, Raghavan S, Hall MD, Patnaik S, Shen M, Kelley RK, Cleary JM, Lawrence MS, Root DE, Patra KC, Silveira VS, Benes CH, Deshpande V, Juric D, Sellers WR, Ferrone CR, Haas W, Vazquez F, Getz G, Bardeesy N. Generation of a biliary tract cancer cell line atlas identifies molecular subtypes and therapeutic targets. Cancer Discov. 2025 May 12;. doi: 10.1158/2159-8290.CD-24-1383. PubMed PMID: 40353839; PubMed Central PMCID: PMC12353624.

Gritti I, Wan J, Weeresekara V, Vaz JM, Tarantino G, Bryde TH, Vijay V, Kammula AV, Kattel P, Zhu S, Vu P, Chan M, Wu MJ, Gordan JD, Patra KC, Silveira VS, Manguso RT, Wein MN, Ott CJ, Qi J, Liu D, Sakamoto K, Gujral TS, Bardeesy N. DNAJB1-PRKACA Fusion Drives Fibrolamellar Liver Cancer through Impaired SIK Signaling and CRTC2/p300-Mediated Transcriptional Reprogramming. Cancer Discov. 2025 Feb 7;15(2):382-400. doi: 10.1158/2159-8290.CD-24-0634. PubMed PMID: 39326063; PubMed Central PMCID: PMC11803398.

Zhang Z, Liu YK, Luo Z, Wu MJ, Evans CN, Qu Z, Xue F, Zhang ZY, Parkinson EI, Bardeesy N, Tao WA. Discovery of Chirally-dependent Protein O-2-Hydroxyglutarylation by D2HG and L2HG. bioRxiv. 2025 Jan 27;. doi: 10.1101/2025.01.24.634716. PubMed PMID: 39975355; PubMed Central PMCID: PMC11838245.

2024

Wu MJ, Kondo H, Kammula AV, Shi L, Xiao Y, Dhiab S, Xu Q, Slater C, Avila OI, Merritt J, Kato H, Kattel P, Sussman J, Gritti I, Eccleston J, Sun Y, Cho H, Olander K, Katsuda T, Shi DD, Savani MR, Smith BC, Cleary J, Mostoslavsky R, Vijay V, Kitagawa Y, Wakimoto H, Jenkins R, Yates K, Paik J, Tassinari A, Saatcioglu DH, Tron A, Hass W, Cahill D, McBrayer SK, Manguso R, Bardeesy N. Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity. Science. 2024; 385: eadl6173. DOI:10.1126/science.adl6173

Zhang Y, Wu MJ, Li YC, Lu WC, Chang CJ, Yang JY. Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer. Cell Metabolism (2024). https://doi.org/10.1016/j.cmet.2023.12.003

2023

Ebrahimi-Nik H, Iracheta-Vellve A, Hamel K, Olander K, Davis T, McGuire K, Halvorsen G, Avila O, Patel C, Kim S, Kammula A, Muscato A, Halliwill K, Geda P, Klinge K, Xiong Z, Duggan R, Mu L, Yeary M, Patti J, Balon T, Mathew R, Backus C, Kennedy D, Chen A, Longenecker K, Klahn J, Hrusch C, Krishnan N, Hutchins C, Aguado J, Bulic M, Tiwari P, Colvin K, Chuong C, Kohnle I, Rees M, Boghossian A, Ronan M, Roth J, Wu MJ, Cheruiyot C, Sen D, Griffin G, Golub T, Bardeesy N, Decker J, Yang Y, Guffroy M, Fossey S, Trusk P, Sun I, Liu Y, Qiu W, Sun Q, Paddock M, Farney E, Beauregard C, Frost J, Yates K, Kym P, Manguso R. PTPN2/N1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity. Nature (2023). https://doi.org/10.1038/s41586-023-06575-7

Shi L, Shen W, Davis M, Kong K, Vu Phuong, Saha S, Adil R, Kreuzer J, Egan R, Lee T, Greninger P, Shrimp J, Zhao W, Wei T, Zhou M, Eccleston J, Sussman J, Manocha U, Weerasekara V, Kondo H, Vijay V, Wu MJ, Kearney S, Ho J, McClanaghan J, Murchie E, Crowther G, Patnaik S, Boxer M, Shen M, Ting D, Kim W, Stanger B, Deshpande V, Ferrone C, Benes C, Haas W, Hall M, Bardeesy N. SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers. Nature Cancer (2023), https://doi.org/10.1038/s43018-023-00523-0. PMID: 36914816.

Cable J, Rathmell JC, Pearce EL., Ho PC, Haigis, MC, Mamedov MR., Wu MJ, Kaech SM, Lynch L, Febbraio MA, Bapat SP, Hong HS, Zou W, Belkaid Y, Sullivan ZA, Keller A, Wculek SK, Green DR, Postic C, Amit I, Benitah SA, Jones RG, Reina-Campos M, Torres SV, Beyaz S, Brennan D, O’Neill LAJ, Perry RJ, Brenner, D. (2023). Immunometabolism at the crossroads of obesity and cancer—a Keystone Symposia report. Ann NY Acad Sci., 00, 1– 13. https://doi.org/10.1111/nyas.14976

2022

Wu MJ, Shi L, Merritt J, Zhu A, Bardeesy N. Biology of IDH Mutant Cholangiocarcinoma. Hepatology. 2022; 75: 1322– 1337. doi: 10.1002/hep.32424

Berchuck J, Facchinetti F, DiToro D, Baiev I, Majeed U, Reyes S, Shroff R, Chen C, Zhang K, Sharman R, Uson Junior P, Maurer J, Shroff R, Pritchard C, Wu MJ, Catenacci D, Javle M, Friboulet L, Hollebecque A, Bardeesy N, Zhu A, Lennerz J, Tan B, Board M, Parikh A, Kiedrowski L, Kelley M, Juric D, Goyal L. The Clinical Landscape of Cell-Free DNA Alterations in 1,671 Patients with Advanced Biliary Tract Cancer. Annals of Oncology (2022), doi: https://doi.org/10.1016/j.annonc.2022.09.150.

Wu Q, Zhen Y, Shi L, Vu P, Greninger P, Adil R, Merritt J, Egan R, Wu MJ, Ferrone C, Deshpande V, Gordan J, Juric D, Goyal L, Benes CH, Bardeesy N. EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma. Cancer Discovery. 2022 May 2; 12 (5): 1378–1395. doi: 10.1158/2159-8290.CD-21-1168

Wu MJ, Shi L, Dubrot J, Merritt J, Vijay V, Wei TY, Kessler E, Olander K, Adil R, Pankaj A, Tummala KS, Weeresekara V, Zhen Y, Wu Q, Luo M, Shen W, García-Beccaria M, Fernández-Vaquero M, Hudson M, Ronseaux S, Sun Y, Saad-Berreta R, Jenkins RW, Wang T, Heikenwälder M, Ferrone C, Goyal L, Nicolay B, Deshpande V, Kohli RM, Zheng H, Manguso RT, Bardeesy N. Mutant-IDH inhibits IFNγ-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma. Cancer Discovery. 2022 March 8; 12 (3): 812–835. doi: 10.1158/2159-8290.CD-21-1077. (Cover story featured in issue)

2020

Kim MR*, Wu MJ*, Zhang Y, Yang JY, Chang CJ. TET2 directs mammary luminal cell differentiation and endocrine response. Nature communication. 2020 Sep 15;11(1):4642. doi: 10.1038/s41467-020-18129-w. (*denotes co-first authors)

2019

Wu MJ, Chen YS, Kim MR, Chang CC, Gampala S, Zhang Y, Wang Y, Yang JY, Chang CJ. Epithelial-mesenchymal transition directs stem cell polarity via regulation of mitofusin. Cell Metabolism. 2019 Apr 2; 29 (4), 993-1002. doi: 10.1016/j.cmet.2018.11.004.

2010-2017

Wu MJ, Kim MR, Chen YS, Yang JY, Chang CJ. Retinoic Acid Directs Breast Cancer Cell State Changes through Regulation of TET2-PKCζ Pathway. Oncogene. 2017 Jun 1; 36(22): 3193-3206. doi: 10.1038/onc.2016.467.

Wu MJ, Chang CJ. High Fat Diet-induced Breast Cancer Model in Rat. Bio-protocol. 2016 Jul 5; 6(13): e1852. doi: 10.21769/BioProtoc.1852.

Wu MJ, Kim MR, Chang CJ. Regulation of microRNA-200c in cancer stem cells. Oncoscience. 2015 Aug 20; 2(9): 745-746. doi: 10.18632/oncoscience.204.

Chang CC*, Wu MJ*, Yang JY, Camarillo I, Chang CJ. Leptin-STAT3-G9a signaling promotes obesity-mediated breast cancer progression. Cancer Research. 2015 Jun 1; 75(11): 2375–2386. doi: 10.1158/0008-5472.CAN-14-3076. (*denotes co-first authors)

Chao CH, Chang CC, Wu MJ, Ko HW, Wang D, Hung MC, Yang JY, Chang CJ. Leptin-STAT3-G9a signaling promotes obesity-mediated breast cancer progression. J Clin Invest. 2014;124(7):3093–3106. doi.org/10.1172/JCI73351.

Chang CW*, Chen CC*, Wu MJ*, Chen YS, Chen CC, Sheu SJ, Lin TW, Chou SH, Lin SC, Liu CJ, Lee TC, Huang CY, Lo JF. Active component of Antrodia cinnamomea Mycelia Targeting Head and Neck Cancer Initiating Cells through Exaggerated Autophagic Cell Death. Evidence-Based Complementary and Alternative Medicine. 2013 Jun 12; 2013: 946451. doi:10.1155/2013/946451. (*denotes co-first authors)

Chen YS, Wu MJ, Huang CY, Lin SC, Chuang TH, Yu CC, & Lo JF. CD133/Src Axis Mediates Tumor Initiating Property and Epithelial-Mesenchymal Transition of Head and Neck Cancer. PLoS ONE. 2011 Nov 28; 6(11): e28053. doi: 10.1371/journal.pone.0028053.

Wu MJ, Jan CI, Yu YH, Huang CY, Lin SC, Chen YS, Tsay YG, Lo JF, and Yu CC (2010). Elimination of head and neck cancer initiating cells through targeting glucose regulated protein78 signaling. Mol Cancer. 2010 Oct 27; 9:283. doi: 10.1186/1476-4598-9-283.